My equipment setup is a bit complex.
Simple is just a guitar.
Then add an amp.
Why not add some effects device to that ? & a looper ?
I now have a combination of analogue and digital.
I use my electric guitar through Guitar Rig pedal board into my Macbook, where it is routed through Bidule into Guitar Rig Software and then optionally Mobius Looper, then outback though the Guitar Rig unit to a valve amp.
The looper is controlled by a FCB 1010 midi unit and I also use a Korg Nanokontrol for extra controlability of settings such as loop feedback etc.
Its not the easiest to setup when you don’t know what you are doing, but the results are fantastic.